Enhanced radiosensitivity and chemoradiation efficacy in nasopharyngeal carcinoma via a dual-targeted SPION@polymer hybrid nanosensitizer

Abstract Cisplatin-based nanoparticles show good potential in enhancing the effect of nasopharynx carcinoma (NPC) therapy but are still limited by their low radiation sensitization and poor tumor targeting ability. Herein, an ingenious design multifunctional superparamagnetic iron oxide nanoparticle (SPION)@polymer hybrid nanosensitizer (SPHN) with enhanced radiosensitization dual-targeting capability is described. SPHN have a core-shell structure, which radiosensitizer particle (SPION) cis-platinum (CDDP) encapsulated RGD-conjugated amphiphilic block copolymers. These unique structures endow outstanding abilities. When combined X-rays, showed strong promotion apoptosis CNE-1 cells vitro. In addition, RNA-seq KEGG enrichment analyses indicated that PI3K-Akt TNF signaling pathways were closely related to molecular mechanism chemoradiotherapy. Furthermore, gene set analysis (GSEA) revealed + X-rays treatment decreased translation initiation cytoplasmic pathway. Through combination chemotherapy, can achieve remarkable inhibition growth vivo, making this nanotechnology general platform for chemoradiation NPC future.